SIMPLE GREEN PURIFICATION OF SPILANTHOL FROM NATURAL DEEP EUTECTIC SOLVENT AND ETHANOLIC ACMELLA OLERACEA (L.) R.K. JANSEN EXTRACTS USING SOLID-PHASE EXTRACTION

Spilanthol is a major N-alkylamide constituent of Acmella oleracea (L.) R.K.Jansen with diverse pharmacological properties.We recently showed the applicability of NADES (natural deep eutectic solvents) for the green extraction of spilanthol.However, the purification of targets from NADES poses a challenging step due to their non-volatility.A simple

Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR)-associated enzyme-CAS holds great promise for treating many uncured human diseases and illnesses by precisely correcting harmful point mutations and disrupting disease-causing genes.The recent Food and Drug Association (FDA) approval of the first CRISPR-based gene therapy for sickle

In 1715 the German Johann Friedrich von Uffenbach, descended from a prosperous Frankfurt family, undertook a four-year journey, the last months of which he spent in Paris, from 11 September 1715 to 11 April 1716.During this period he made two day trips to Versailles, on 17 September 1715 and a few days later on 21 Motor Armature Refacing Stick Sept

For the test patterns conversion complexity and workers high Nuts work intensity of locomotive test, a new design scheme of synchronous control system was presented.Converter control pattern changing and optimization of Cleaning Machines synchronous gear box design method was provided, which could realized vehicle dynamic test three control modes c